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Pet scan showing a
sarcoma in the leg that has spread to the lymph node |
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The
diagnosis of cancer
generally requires a biopsy or tissue specimen. The pathologist then reviews the
specimen and makes a histologic diagnosis, (Occasionally cancer cells can be found in
fluid or tissue scrapings like a Pap smear, and a cytological diagnosis of cancer can be
made.) Multiple myeloma creates a pattern of abnormal proteins in the blood or urine
(immunoglobulin) that helps make the diagnosis. Surgeons try to limit the
extent of surgery necessary to make a diagnosis (see sentinel node biopsy
section here).
Some cancers produce chemicals that can be measured in the blood (notably PSA for prostate
cancer and CA-125 for ovarian cancer) called tumor markers. Many cancers do not produce
such markers and so blood tests may not reveal cancer. (see section on tumor markers and PSA.)
X-rays or imaging studies can often identify the extent and sites of
spread of cancers, but there are also limitations (many breast cancers in young women will
not be visible on mammograms and lung cancers are hard to identify early on conventional
chest X-rays. Imaging has come a long way in the past century (see here, here and here).
PET scans have been a significant improvement for many sites of cancer. (see sections on brain imaging, PET scans,
mammograms/breast MRI and, lung imaging.)
Details on diagnostic studies are described in the section on
anatomy and
imaging.
Despite high levels of tumor markers or clearly malignant
appearing cancers on X-rays or PET scans a biopsy is still often necessary to be 100% sure
of the diagnosis of cancer. Exceptions can be made when attempts to get a tissue diagnosis
are too risky (e.g. deep brain tumors or hard to reach lung lesions.) |