Melanoma is the third most common cancer causing brain metastases in the United States, after cancers of the lung and breast, which appears to reflect the relative propensity of melanoma to metastasize to the central nervous system. Brain metastases are responsible for 20 to 54 percent of deaths in patients with melanoma, and among those with documented brain metastases, these lesions contribute to death in up to 95 percent of cases (read review here)

Unfortunately brain metastases are quite common in patients with advanced melanoma. These do not respond well to chemotherapy, and since melanoma is somewhat radio resistant  they often do not respond well to conventional whole brain external beam irradiation. So if there is a single brain met it is common to treat this with surgery or radiosurgery. It there are more than one (up to three or five) then radiosurgery may be the most appropriate option.  If there are many separate mets or there is widespread disease elsewhere in the body, then whole brain radiation is used.

Read review article here.

                                          Some of the studies are noted here , here , here and see patient information here