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The lymph nodes in the neck (called cervical nodes) are common sites of spread from cancers in the head and neck area. The staging system (1983 AJCC) was as follows:
N1 = single node up to 3 cm in size
N2  = >3cm and up to 6cm (N2a single and N2b multiple)
N3 = over 6cm or bilateral (N3a ipsilat, N3b bilateral, N3c contralateral)
The current stage system (AJCC 5th ed.)
N1 = single node up to 3 cm
N2 = > 3cm up to 6cm (N2a single, N2b multiple, N2c bilateral)
N3 = over 6 cm

 

The treatment of metastatic cancer in the lymph nodes is related to the type of cancer and the size of the nodes. Some node cancers (e.g. lymphoma) are very sensitive to radiation (or chemotherapy) and surgery is not indicated. Most head and neck cancers are squamous cell carcinomas and for large nodes surgery is necessary (except nasopharynx cancer where surgery is less often used.) For patients with multiple nodes chemotherapy probably plays an increasing role. In  general  a small single node up to 2-3 cm (so called N1) can be treated adequately with surgery (usually a radical neck dissection) or radiation. Larger nodes or  multiple nodes (N2 or N3) usually require combined surgery and radiation. In the past surgery was always a radical neck dissection but there has been increasing use of more limited resections. Also some nodes (e.g. retropharyngeal nodes) cannot be resected and radiation is always indicated. The risk of   spread to these nodes is noted below:

Retropharyngeal Node Metastases (McLaughlin Head and Neck 1995;17:190)
Primary Site Risk of Node Spread
nasopharynx 74%
pharyngeal wall 19%
soft palate 13%
tonsillar region 9%
pyriform/ postcricoid 5%
base of tongue 4%
supraglottic larynx 2%

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