Pain from cancer is a major health care problem. Thirty percent of
patients with cancer have pain at the time of diagnosis, and 65 to 85 percent have pain
when their disease is advanced. The impact of cancer pain is magnified by the interaction
of pain and its treatments with other common cancer symptoms: fatigue, weakness, dyspnea,
nausea, constipation, and impaired cognition. Cancer pain can be
effectively treated in 85 to 95 percent of patients with an integrated program
of systemic, pharmacologic, and anticancer therapy. Many of the remaining patients can be
helped by the appropriate use of invasive procedures. In the final days of life, pain not
controlled by therapies aimed at both comfort and function can be relieved by intentional
sedation. No patient with cancer needs to live or die with unrelieved pain. Michael H.
Levy The New England Journal of Medicine -- October 10, 1996 -- Vol. 335, No.
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