RADIATION THERAPY ONCOLOGY GROUP RTOG P-0011
PHASE III RANDOMIZED STUDY OF ADJUVANT THERAPY FOR HIGH RISK pT2-3N0 PROSTATE CANCER
Radiation Therapy: 63.0-66.6 Gy in 35-37 fx (1.8 Gy in 5 daily sessions per week) to
the original prostate volume,
the tumor resection bed, and the proximal membranous urethra.
Planning Target Volume Calculation
The planning target volume (PTV) will add 0.5 cm circumferentially
for day-to-day variation in set up and will add an additional 1.0 cm posteriorly and 0.5
cm superiorly for
CTV motion associated with variability in rectal and bladder filling.
Field Borders will add 1.5 cm outside the PTV. The individually shaped anterior,
posterior, right and left
lateral fields will have the following radiation field borders when the patient is judged
to have had a
normal sized prostate (prostatic urethral length of 4.0 cm) prior to surgery and have had
no microscopic
involvement of the seminal vesicles
Inferiorly: a border that is 2.0 cm inferior to the apex or the beak of the
contrast held under pressure in the
penile urethra.
Superiorly: 2.5 cm beyond the calculation of the original superior extent of the
lateral lobes of the prostate
(or further superior if microscopic seminal vesical disease was identified). This field
should be, as a
minimum 9.5 cm in the longitudinal (cranial to caudal) axis.
Posteriorly: 2.5 cm posterior to the most anterior portion of the anterior rectal
wall.
Anteriorly: 1.0 cm posterior to the anterior tip of the symphysis laterally.
Laterally: the field should cover as a minimum the lateral margins of the obturator
foramen.