malignant rectal polyps (see pics) are generally removed
through an endoscope, some of these patients may need further therapy as noted below (if
surgery is recommended but refused, then postOp irradiation is often used, but there is
little evidence that this is equivalent.) See discussion
guidelines, and other
guidelines for additional therapy after a polypectomy.
Endoscopy and snare polypectomy provide a simple and cost-effective means of managing colorectal polyps.In practice, all polyps should be considered for removal. Polyps that are smaller than 5 mm, also referred to as diminutive polyps, usually are benign, rarely produce bleeding, and may be left in place if they are multiple. But at least three to five of the polyps should be removed for histologic examination they should all be removed subsequently if found to be adenomas.
It often is not possible to determine the histologic type by gross visual appearance, but polyps larger than 2 cm in size usually are adenomatous and should be removed in toto if pedunculated. If sessile, they may need to be removed piecemeal, although the histologic evaluation of the presence or degree of invasion of any carcinomatous foci would then be difficult or impossible.If there is any concern that residual polyp tissue may be left, the polypectomy site should be tattooed with sterilized India ink to facilitate follow-up evaluation. This should also be done if there is a high index of suspicion that a polyp may be malignant at the time of polypectomy, or as a secondary procedure after this has been confirmed histologically, prior to definitive surgery if this is indicated. The number of polyps that can be removed safely depends on their location and size. In the patient with a diagnosis of FAP, colectomy, not polypectomy, is indicated. For multiple adenomatous polyps, where there is the possibility of removing them endoscopically, the colon should be cleared of polyps a section at a time to reduce the chance of complications. The wall thickness of the cecal area and right colon is thinner than that of the left, which also must be considered when removing polyps through cautery. If polyps are inflammatory, hyperplastic, or otherwise nonadenomatous by histologic examination, complete removal is unnecessary, but a sampling of several polyps from each cluster is required, particularly if there is a suspicion of intercedent malignancy.
Polypectomy is safe in adults and children when performed by experienced physicians. The major complication rate is less than 2%, the requirement for hospitalization or surgical intervention less than 0.3%, and death is virtually nonexistent. Polypectomy should be deferred in patients on aspirin or anticoagulation, or in those with severe bleeding diatheses, unstable cardiac arrhythmias, recent myocardial infarction, acute colitis, pregnancy (second or third trimester), recent colonic surgery, or abdominal abscess or perforation.
When an adenoma is found, surveillance colonoscopy after 3 years suffices provided the colonoscopist has reasonable confidence that polypectomy is complete, and adequate views have been secured of the entire colon. If the repeat surveillance colonoscopy is clear at a further 3 years, scheduling may be reduced to every 5 years. For patients at higher risk for colorectal cancers, such as those at risk because of hereditary nonpolyposis colorectal cancer, more frequent examinations may be in order. On the other hand, patients with only small tubular adenoma(s) in the rectum are not at increased risk for colorectal cancer and can be dismissed from follow-up or offered repeat examination at 5 years.
In cases in which a polyp is large and sessile, or otherwise cannot be removed by endoscopic polypectomy, surgical resection may be necessary. Surgical resection is also indicated for some adenomas with invasive carcinoma (malignant polyps).Large rectal adenomas may be extirpated by transanal excision using an operating sigmoidoscope and rigid snare under anesthesia or with an operating microscope in association with a sigmoidoscope. Other large polypoid lesions and malignant polyps need to be removed by laparotomy. Resection of a large villous adenoma of the colon delivered laparoscopically outside the abdominal wall through a small skin incision is possible. Once laparotomy is indicated, many surgeons advocate the use of a formal segmental colectomy including lymph node dissection. The rationale is that when a laparotomy is required for lesions above the peritoneal reflection, a formal hemicolectomy adds little or no additional anesthesia time or perioperative mortality and morbidity. The patient's willingness, however, to assume some risk for potential undertreatment for disease and the patient's ability to maintain surveillance also are factors that should be considered in any therapeutic decision.
Severe Dysplasia and Intramucosal Carcinoma
These nonmalignant adenomas are cured by adequate polypectomy.
The progression of severe dysplasia to intramucosal car-cinoma and invasive malignancy demands careful management and complete removal. Evaluation of a removed polyp by fragmental biopsy or piecemeal polypectomy is diffi-cult. The presence of cancerous cells on a biopsy or cytology specimen does not reveal the malignant nature of a polyp without the contextual morphology provided by retrieval of a single specimen in toto. Furthermore, biopsy may miss an area of invasive carcinoma or be too superficial to make this diagnosis. Only careful examination of serial sections of the entire polyp after removal is adequate for proper evaluation. This, of course, is a doctrine of perfection because it is sometimes impossible to remove a polyp in a single specimen.
When severe dysplasia is noted, careful examination of multiple sections must be done. When a polyp contains malignant cells that have penetrated the muscularis mucosae, it is termed a malignant polyp. (see stage) The proper management of malignant polyps remains controversial. There have been no prospective trials evaluating the natural history of malignant polyps or their optimal management strategy. Many features of malignant polyps have been studied for their predictive potential.
There is general agreement that poor prognostic features include incomplete resection, poorly differentiated carcinoma, and malignancy present within 2 mm of the polypectomy margins.More controversial prognostic factors are involvement of venous or lymphatic channels with malignancy, replacement of the bulk of the adenoma by carcinoma, and large polyp size. Some studies suggest that the presence of venous or lymphatic invasion is a grave prognostic factor, and that these patients should undergo colon resection. Lymphatic invasion is, however, subject to observer variability.Malignant polyps with venous (or lymphatic) invasion are almost always associated with higher grade cancers, recurrences, and metastases, but the studies have been mostly retrospective reviews. Sessile malignant polyps are also considered to have a worse prognosis. In one study, 7 of 34 patients with sessile polyps had local recurrence or distant metastases within 6 years, compared with none of 47 patients with pedunculated polyps. Again, most of the sessile polyps usually have other poor risk markers.Of those with pedunculated polyps, most had invasion limited to the head, neck, or stalk, although one patient had invasion to the base of the stalk. Of 62 evaluable patients who also had endoscopic polypectomy, 4 had recurrence (or distant cancer of unknown origin) within 5 years, giving a recurrence rate of 7%.
In other studies, patients who underwent endoscopic polypectomy for pedunculated malignant polyps did better. In one study, 19 patients with pedunculated malignant polyps (average size 3 cm), with one polyp showing venous invasion, were all asymptomatic after 1 to 6 years.In another retrospective review of 43 patients with pedunculated malignant polyps who were followed for almost 5 years, 19 patients initially underwent colon resection because of physicians' clinical judgment. Of these 19 patients, as well as the 24 who had polypectomy alone, none had cancer recurrence. Of the 13 evaluable patients with sessile polyps, all underwent colon resection, and Dukes B or C cancer was found in. None has had cancer recurrence after almost 5 years.
Most data indicate that polypoid carcinomas (which have no residual adenomatous tissue) do not spread and therefore do not require segmental resection unless poor prognostic features are present.
These guidelines, however, are derived from incomplete studies, and it is difficult to be rigid in their application. For the individual patient, it is necessary to weigh the estimated risks of surgery against the risks of leaving residual malignancy in situ after endoscopic polypectomy of a malignant polyp. The presence of poor prognostic features should lead the physician to favor colectomy but the decision should always be temporized by the age of the patient and any coexistent morbidity. The decision depends on an estimate of the risk that residual cancer is present versus the operative risk if surgery were undertaken. The latter increases with low rectal lesions, advancing age, and comorbidity.
Operative mortality ranges from 2% to 10%, increasing with the age of the patient. Because most patients with malignant polyps are in their seventh and eighth decades of life, the risk of colectomy is significant. Colectomy would be of little or no benefit if distant metastases are already present at the time of surgery.
Based on current evidence, the following recommendations for management of malignant polyps can be made (see figure)
1. A pedunculated malignant polyp with invasion of the head, neck, or
stalk is adequately treated by polypectomy alone if the polypectomy was not piecemeal, the
cancer was not poorly differentiated, and the resection margin was free of cancer for 2