Survival with Brain Metastases

Survival for Patients with Brain Metastases

Stage Groups for Palliative Radiation from RTOG Trials (IJROBP 1997;37:745)
Stage	Characteristics	Median Survival
I	KPS>70, primary controlled, age <65y, mets to brain only	7.1 months
II	KPS >70	4.2 months
III	KPS < 70	2.3 months

Median Survival Brain Mets by Therapy
Therapy	Median Survival
No Therapy	1 month
Steroids only	2 months
Radiation	3 - 6 months
Surgery	6 - 14 months

Survival with Brain Metastases by Radiation Response
Response to Radiation	Survival
complete response	33 - 49 weeks
partial	20 weeks
none	9 - 14 weeks

Survival with Brain Mets by Functional Status
Neurologic or Functional Class	Survival in Weeks
I. Working	27 weeks
II. Home	17 weeks
III. Hospitalized	14 weeks
IV. Coma	5 weeks
Ambulation
Ambulatory	21 weeks
Non-Ambulatory	12 weeks

Survival with Brain Mets by Favorable Factors
# of Favorable Factors	Survival in Months
0	1.8 mos
1	2.6 mos
2	3.3 mos
3	5.0 mos
4	7.4 mos

Factors: PS > 70, Age < 60, primary controlled, no other metastases

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