Diethylstilbestrol is a crystalline synthetic estrogenic substance capable of producing all the pharmacologic and therapeutic responses attributed to natural estrogens. Diethylstilbestrol may be administered orally.

INDICATIONS AND USAGE:

1. Breast cancer (for palliation only) in appropriately selected women and men with metastatic disease

2. Prostatic carcinoma--palliative therapy of advanced disease

WARNINGS:

In a large prospective clinical trial in men, (REF. 38) large doses of estrogen (5 mg of conjugated estrogens per day), comparable to those used to treat cancer of the prostate and breast, have been shown to increase the risk of nonfatal myocardial infarction, pulmonary embolism, and thrombophlebitis. When such large doses of estrogen are used, any of the thromboembolic and thrombotic adverse effects associated with the use of oral contraceptives should be considered a clear risk.
 

DOSAGE AND ADMINISTRATION:

Inoperable progressing prostatic cancer

1 to 3 mg daily initially, increased in advanced cases; the dosage may later be reduced to an average of 1 mg daily.
 

HOW SUPPLIED:

Tablets:

The 1 mg tablets are white, round, and engraved with script "Lilly" and "J52".

Bottles of 100: NDC 0002-0122-02 (TA 1649)

The 5 mg tablets are white, round, and engraved with script "Lilly" and "J53".

Bottles of 100: NDC 0002-1054-02 (TA 1685) Store at controlled room temperature 15° to 30° C (59° to 86° F).