Postmastectomy radiation to the axilla

 

Studies show that radiation to the axilla will increase lymphedema, so it should not be routinely performed. Data from the MD Anderson series (mastectomy with postOp chemoRx but no radiation as reported by Katz ONI May 2001:41)

Location of Local Relapses of the 19% (179/1031) who developed them
Site Percent
Chest Wall 68%
SurpaClav Nodes 40%
Axilla 14%
Internal Mamm Nodes 8%
Infraclavic Nodes 7%
They noted that the risk of relapsing in the axilla if a dissection was performed was quite small (3% at 10 years) but higher in the undissected cases (8%/10years.) The risk factors were only significant in the undissected axilla as shown:

Axilla Relapse by Risk Factors at 10 Years
Risk Factor Undissected Axilla Dissected Axilla
4 or more nodes + 15% 5%
> 20% of nodes involved 14% 5%
2mm or more extranodal 20% 5%

they conclude that only patients with undissected axilla and one of these risk factors should get the axilla radiated