Histologic Criteria of the World Health Organization for the Classification of Gliomas.
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Fibrillary astrocytoma is characterized by increased cellularity with a monomorphic population of cells infiltrating the neuropil (Panel A, hematoxylin and eosin).

 

 

Anaplastic astrocytoma is characterized by nuclear atypia and mitoses (Panel B, hematoxylin and eosin)

 

Glioblastoma multiforme is characterized by necrosis with cells arranged around the edge of the necrotic tissue (pseudopalisading cells) (Panel C, hematoxylin and eosin); vascular proliferation is apparent at the top of the image.

  

 

 

 

 

 

 

 

 

It's important to distinguish between low grade gliomas (which have a better prognosis) from anaplastic (or grade 3 gliomas) which are more serious and from Glioblastoma Multiforme (or grade 4) which are the most serious