RTOG Malignant Glioma Prognostic Groups

In order to use this table, first determine the histology, either anaplastic astrocytoma (AA) or grade III glioma (which is better) or Glioblastoma Multiforme (GBM which is worse.)

The consider the patient's mental status (MS, i.e. how mentally impaired he is from the tumor) then consider the patient's overall functional status (Karnofsky Score which is explained elsewhere.)

Then also consider the duration of the symptoms (if the tumor has come on rapidly, less than 3 months, that is more serious.) Then based on age you can fit the patient into one of the prognostic classes (I through VI)

**RTOG Malignant Glioma Prognostic Groups**
Class	Age	Histo	MS	KS	Sym.Dur.
I	< 50y	AA	normal
II	>50y	AA		70-100	> 3mos
III	<50y	AA	abn
	<50y	GBM		90-100
IV	<50y	GBM		<90
	>50	AA		70-100	< 3 mos
	>50y	GBM	working	70-100
V	>50y	GBM	can't work	70-100
	>50y	GBM	biopsy only	70-100
	>50y			<70
VI	>50y	GBM	biopsy	70-100	low dose XRT
	>50y		abn	<70

Histo (histology, either anaplastic astrocytoma or glioblastoma) MS (mental status) KS (Karnofsky Score) Sym Dur (duration of symptoms) low dose XRT (< 54Gy)

Curran Journal NCI 1993;85:704